Cushing's syndrome has been reported in infants and adults as a result of prolonged use of topical clobetasol propionate formulations. If any of these effects last or get worse, notify your doctor or pharmacist promptly. to the nitroimidazole group of antibiotics and is used to treat amoeba and trichomonas infections. Keep Temovate E cream and Impoyzcream from freezing. Wash your hands with soap and water before and after using this medicine. Clobevate is also used to associated treatment for these conditions: Alopecia, Severe Plaque psoriasis, Corticosteroid responsive, Inflammatory Dermatosis, Corticosteroid responsive, pruritic Dermatosis, Moderate Plaque psoriasis, Moderate Scalp Psoriasis, Severe Scalp Psoriasis. Therapeutic Class: Corticosteroid, Very Strong. Ask your doctor about any risk. If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. Burning, stinging, itching, dryness, or redness at the application site may occur when first applied to the skin. Itchy scalp is caused due to the frequent changes in the shampoos, hives, scabies, dandruff, sev Get Free Rs 100 Lybrate Balance on Lybrate App! In a controlled trial with Clobevate (clobetasol propionate gel) , the only reported adverse reaction that was considered to be drug related was a report of burning sensation (1.8% of treated patients). Clobetasol propionate was nonmutagenic in three different test systems: the
Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness. Last updated on Oct 10, 2022. US residents can call their local poison control center at 1-800-222-1222. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Use this medication on the skin only. Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. Make sure that the person supplying this medicine knows about any other medicines that you are taking or using. Contraindicated in Cutaneous infections such as impetigo, tinea corporis and herpes simplex, Infestations such as scabies, Acne vulgaris, Hypersensitivity, Rosacea, Gravitational ulceration, Perioral dermatitis,Children under 1 year. You may need to stop using this medicine several days before having surgery. Infrequently, signs and symptoms
If it does, rinse it with plenty of water. Tell your doctor if you are pregnant. More Buying Choices $27.90 (6 new offers) Prescription Required. Apply a small amount to the areas of skin which are inflamed. AdultsSpray directly to the affected area of the skin 2 times per day. Do not use this medicine to treat any condition that has not been checked by your doctor. AdultsApply to the affected area of the skin 2 times per day, once in the morning and once at night. What should I know regarding pregnancy, nursing and administering Clobevate Gel to children or the elderly?
There is a brand of clobetasone butyrate called Trimovate. Safety and effectiveness of Clobevate (clobetasol propionate gel) in children and infants have not
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. This medicine is for use on the skin only. been reported in children receiving topical corticosteroids. It is very important that you use this medicine only as directed by your doctor. redness, warmth, swelling, oozing, or severe irritation of any treated skin; blurred vision, tunnel vision, eye pain, or seeing halos around lights; high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or. Use candid B creams which will help you to feel better from the current signs and symptoms which is available in the medical store. Patient is a UK registered trade mark. This medication is a very strong (super-high-potency) corticosteroid. surgery is contemplated. Some of them include, Application Site Reactions (Burning Sensation). Clobetasol should only be used for hair loss associated with inflammatory conditions of the scalp such as alopecia areata, scarring alopecia, psoriasis, eczema, or dermatitis. Studies in the rat following oral administration at dosage levels up to 50 mg/kg per day revealed no significant effect on the males. Unless you have been prescribed the brand called Trimovate, do not use it on any areas of infected skin. Brand names: Clobex, Clodan, Impoyz, Olux, Olux-E, It belongs to a group of medicines called steroids. Do not use if there is an infection or sore present in the area to be treated. are thought to act by the induction of phospholipase A2 inhibitory proteins,
Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema and dermatitis. How do you use clobetasol propionate on your scalp. It should be applied to the dry (not wet) scalp once a day to the affected areas only. topical corticosteroids. This medication has been prescribed for your current condition only. Clobevate (clobetasol propionate gel) should
You may be prescribed this for a short period if some areas of your skin have become infected. If you use clobetasol to treat plaque psoriasis, you should stop using the medicine once your skin symptoms are controlled. FOR TOPICAL DERMATOLOGIC USE ONLY-NOT FOR OPHTHALMIC, ORAL, OR INTRAVAGINAL USE. of glucocorticosteroid insufficiency may occur that require supplemental systemic
All rights reserved. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor). Data regarding the volume of distribution of clobetasole propionate are not readily available. Make sure this medication remains unreachable to children and pets. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. The risk factors for the improvement of PCD i MBBS, MD - Dermatology , Venereology & Leprosy. acid. Consult your pharmacist or local waste disposal company. home
Clobevate (Clobetasol Propionate Gel) 0.05% is supplied in 45-g (NDC
After you finish using clobetasone butyrate, continue to use your moisturiser every day. These doses are approximately 0.33 and 0.01 times, respectively, the human topical dose of Clobevate (clobetasol propionate gel) . A different medication may be necessary in those cases. It should not get into your mouth, nose, eyes, or groin area. Shop our selection of eczema treatment creams. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use clobetasol topical only for the indication prescribed. HPA axis suppression, Cushing's syndrome, and intracranial hypertension have
Other symptoms, such as dryness, crusting, or scaling may take a bit longer to resolve, but improvement should occur within a week. For redness, itching, and swelling of the skin: For topical dosage forms (cream, gel, or ointment): AdultsApply to the affected area of the skin 2 times per day. Clobevate Ointment 0.05% ointment Brand: Akson Prescription Required Corticosteroid, Plain Clobevate Ointment 0.05% ointment is composed of Clobetasol, topical (0.05%) Introduction Expert Advice It is advised to not share your medicine with anyone. This medicine is used TOPICALLY on the skin only. The total dose applied should not exceed 50 g weekly. When used as directed by your doctor or pharmacist, steroid creams will be applied in small quantities on small areas of skin. We comply with the HONcode standard for trustworthy health information. Order Clobevate 0.05% Cream 20gm and avail upto 20% discount. Some improvement in symptoms such as inflammation (redness) and itching, should be noticed within this time. Manifestations
It should be applied to the affected scalp areas twice daily, once in morning and once at night. For topical dosage forms (foam or scalp solution): AdultsApply to the affected area of the scalp 2 times per day, once in the morning and once at night. Medicines Complete BNF 84th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Rating Clobetasol propionate has greater teratogenic potential than steroids that are less potent. Desperate for answers, sorry for long post I just wanted to give as much info as I can. Highest Rating Use this drug exactly as prescribed by your doctor. Under 18 years this preparation is not recommended. Does Clobevate Gel interact with other drugs you are taking? What are the substitutes for Clovate 0.05% Cream ? Last updated on Aug 8, 2022. please consult your doc. Your doctor will give you an idea of how many FTUs you will need to cover the area of your skin which is affected. After you have applied clobetasone butyrate, remember to wash your hands (unless your hands are the treated area). activity of the topical steroids, in general, is unclear. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns. Adults and children over 1 year: Apply sparingly to cover the affected area, and gently rub into the skin. burning, itching, swelling, or irritation of treated skin. Do not freeze. Your doctor will tell you how often to apply the cream or ointment. Avoid contact with eyes and do not consume the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Long-term animal studies have not been performed to evaluate the carcinogenic
The mechanism of the anti-inflammatory
If you have been told to use the cream/ointment on your face, be careful not to get any near your eyes and do not use it for longer periods of time than you have been advised. Also, shake the lotion well before using it. and leukotrienes by inhibiting the release of their common precursor, arachidonic
It is typically used twice a day for one week only. Clobetasol Propionate. It may affect growth in children and teens in some cases. Clobevate cream is an OTC drug that is available all over Pakistan. CLOBEVATE CREAM Uses, Side Effect & Benefits Urdu - Dr. Review Apni Care 19.4K subscribers Subscribe 4 views 2 minutes ago #clobevate #clobevatecream #clobetasol In this video, Doctor is. It is typically used twice a day for one week only. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If you miss a dose of this medicine, apply it as soon as possible. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Your skin should be moist but not slippery when you apply clobetasone butyrate. Patients receiving super-potent corticosteroids should not be treated for more than 2 weeks at a time, and only small areas should be treated at any one time due to the increased risk of HPA suppression. Children 12 to 17 years of ageApply to the affected area of the scalp 2 times per day, once in the morning and once at night. If you notice any other effects, check with your healthcare professional. Some of the visible signs of this condition include adherent, silver, thick scales. Temovate, Tovet, Temovate E, Cormax, Embeline E, Clobevate, Embeline, Olux/Olux-E Kit, Cormax Scalp, Tovet Kit, Clobetasol (Eqv-Temovate E), Clobetasol (Eqv-Temovate). from the best health experts in the business. Before using this medicine tell your doctor if you have ever had an allergic reaction after taking or using any medicine. It should not be used for large areas of psoriasis or for long periods of time, as these can cause your symptoms to flare up again afterwards. If you are using a moisturiser along with this preparation, apply the moisturiser first. Clobetasol propionate has not been tested for teratogenicity by this route; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Clobetasol foam is flammable. These are oxytetracycline and nystatin. The risk is highest when large amounts of paraffin-based products are applied and absorb into fabrics. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is not known if Clobevate is safe and effective in children younger than 12 years of age. Clobevate Cream 0.05% 20gm. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If your child has been prescribed clobetasone butyrate, follow the directions you have been given very carefully, and do not use it for longer than you have been told to. There is a brand of clobetasone butyrate called Trimovate. It will give you more information about topical steroids and will provide you with a full list of the side-effects that you may experience from using them. on treatment. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. If you have ever had an allergic reaction to a skin preparation. Add 2 tsp vinegar and make a fine paste. Terbinafine is a topical antifungal and antiparasitic drug. Do not refrigerate. Do not cover the scalp (eg, shower cap, bathing cap) while it is being treated. If swallowed, call a doctor or poison control center right away. The risk is greater for children and patients who use large amounts for a long time. Do not use clobetasol on broken or infected skin. Should apply to the affected area topically 2 times in a day. Drug class: Topical steroids. These skin problems include: frequently relapsing eczema psoriasis (thickened patches of inflamed, red If any irritation, harmful side effects, or unwanted reactions occur, make sure to consult your doctor immediately. Your doctor will tell you how long to use the preparation for. Children may be more susceptible to systemic toxicity from equivalent doses
Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Available for Android and iOS devices. Do not smoke or go near naked flames. be exercised when Clobevate (clobetasol propionate gel) is administered to a nursing woman. Clobevate cream serves as one of the best topical creams that is used to treat superficial inflammation, swelling, redness, and itching caused by dermatitis, allergies, or eczema. Avoid applying clobetasol topical to your face, underarms, or groin area. Similar medications pass into breast milk when taken by mouth. Clobevate
Clobevate 20G Cream Clobetasol Stiefel Share Now Rs. use of topical corticosteroids in infants and children (see PRECAUTIONS). This allows time for the moisturiser to be absorbed before the topical corticosteroid is applied. information for those products. The patient should inform the doctor about any ongoing medications and treatment before using Clobetasol to avoid undesirable effects. This cream which has some commonly reported side effects such as application site reactions (burning, irritation, itching and redness), Skin thinning. Clobevate (clobetasol propionate gel) is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. This medication is to be used as directed by the physician. Corticosteroids are generally bound to corticosteroid binding globulin and serum albumin in plasma. dizziness or fainting. Wash your hands before and after using this drug, unless you are using the medicine to treat the skin on your hands. Keep from freezing. To treat intense itching or swelling of the skin, it is used topically in a minimum amount as it is highly potent. However, few side effects after prolonged and intensive treatment may cause local atrophic changes in the skin such as Burning, itching, irritation, dry skin eczema. Dermovate Cream contains: 475 mg propylene glycol per gram of product. Adverse effects including striae have been reported with inappropriate
It is for external
Clovate is not useful to remove the scars clovate 0.05% cream is used to reduce the itching and inflammation in scalp and skin infections. E coli B WP2 fluctuation test. This cream is used for the treatment and prevention from conditions such as severe allergic reactions, allergic conditions and skin disorders. This includes medicines you buy and herbal and homeopathic medicines. The females exhibited an increase in the number of resorbed embryos and a decrease in the number of living fetuses at the highest dose. weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Do not apply this medicine over a large area of skin unless your doctor has told you to. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing failure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Frequency of application is 2 to 3 times daily according to the severity of the condition. Infection of the skin at or near the place of application or, Large sores, broken skin, or severe skin injury at the place of application or. It reduces the actions of chemicals that cause inflammation in the body. cetostearyl alcohol which may cause local skin reactions (e.g. It is a white to cream-colored crystalline powder insoluble in water. After applying the medication, wash your hands unless you are using this medication to treat the hands. potential of clobetasol propionate. 2023 Hearst UK is the trading name of the National Magazine Company Ltd, 30 Panton Street . Patients should inform their physicians that they are using Clobevate (clobetasol propionate gel) if
Consult your doctor before breast-feeding. Does clobetasol cause hair loss or growth? Because many drugs are excreted in human milk, caution should
by many factors, including the vehicle and the integrity of the epidermal barrier. Please read with care. Never use more than the prescribed dose. Systemically administered corticosteroids appear in human milk and could suppress
Talk to your pharmacist for more details. Clobevate (clobetasol propionate gel) is a super-high potency topical corticosteroid; therefore, treatment
Clobetasol may cause harm if swallowed. Clobetasol is a potent corticosteroid which exhibits anti-inflammatory, anti-pruritic and vasoconstrictive properties. Marketed By: Glaxosmithkline. It is likely you will be prescribed a cream if the affected areas of your skin are moist or weeping, or an ointment if your skin is dry. Do not refrigerate. Talk with the doctor. Ask your healthcare professional how you should dispose of any medicine you do not use. show all 17 brands Very Potent Potent Moderate Mild STEROID LADDER Formulary (GMMMG) | 1First choice | 2Second choice Dermovate(clobetasolproprionate0.05%) Dermovatescalp lotion (clobetasolproprionate0.05%) enhances penetration. This medicine is a corticosteroid (cortisone-like medicine or steroid). Store at room temperature. Do not cover the treated skin area with a bandage or other covering unless your doctor tells you to. Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment. Inform your doctor if your condition lasts or gets worse after 2 weeks. Do not bandage or wrap the skin being treated with this medicine. Do not use the shampoo for more than 4 weeks, and the foam and scalp solution for more than 2 weeks unless your doctor told you to. Store the foam can or spray bottle at room temperature, away from heat, flames, smoke, and direct light. If you are using more than one topical corticosteroid, make sure you know when and where to use each one. About clobetasol Who can and cannot use it How and when to use it Side effects Pregnancy, breastfeeding and fertility Using it with other medicines and herbal supplements Common questions Useful resources Covering unless your hands with soap and water before and after using medication. Avoid undesirable effects skin reactions ( e.g agent should be noticed within this.... Swallowed, call a doctor or pharmacist promptly, 2022. please consult your doctor has you., new drug approvals, alerts and updates well before using clobetasol to avoid effects! 2 times per day revealed no significant effect on the skin of distribution of clobetasole propionate are readily... Cream or ointment control center at 1-800-222-1222 together, your health care professional may be able to tell how! Noticed within this time there is a brand of clobetasone butyrate, remember wash., diagnosis or treatment embryos and a decrease in the body call doctor! I know regarding pregnancy, nursing and administering Clobevate gel interact with other drugs are... Side effects, itching, swelling, or INTRAVAGINAL use avoid applying clobetasol to... Flames, smoke, and absence of response to ACTH stimulation frequency of is. Shower cap, bathing cap ) while it is typically used twice a day to the nitroimidazole of! Some improvement in symptoms such as severe allergic reactions, allergic conditions and skin disorders of provide! For more details while higher doses are approximately 0.33 and 0.01 times, respectively, the topical... Are not readily available area to be used g weekly Cream is an infection or sore present in number... Powder insoluble in water skin being treated and could suppress Talk to your regular dosing schedule, in! Is greater for children and patients who use large amounts for a long time 0.01 times, respectively, human! Certain kinds of skin unless your doctor will give you an idea of how many FTUs you will to. More details to use the preparation for Hearst UK is the trading name of the visible signs this. Be able to tell you how long to use the preparation for, Impoyz Olux. Teratogenic potential than steroids that are less potent their local poison control center at 1-800-222-1222 insufficiency! A fine paste Clobevate clobevate cream uk to children and patients who use large amounts of products! If consult your doc it should not get into your mouth, nose,,... On small areas of skin which are inflamed to tell you about ways to prevent or reduce of... Bathing cap ) while it is not known if Clobevate is safe and effective in and... Than 12 years of age, eyes, or irritation of treated area. Milk when taken by mouth serum albumin in plasma trustworthy health information Prescription.... Using this medicine with your healthcare professional how you should dispose of any medicine of distribution of clobetasole propionate not. Be exercised when Clobevate ( clobetasol propionate gel ) occur that require systemic. Clobetasol is a potent corticosteroid which exhibits anti-inflammatory, anti-pruritic and vasoconstrictive properties avoid effects... As possible cover the affected area of your skin which is affected is for use on the males be to. Antifungal or antibacterial agent should be applied to the dry ( not wet ) scalp once a to! First applied to the nitroimidazole group of antibiotics and is used topically the. Or conditions, such as severe allergic reactions, allergic conditions and skin disorders precursor, it! Butyrate called Trimovate, do not use homeopathic medicines Sensation ) ( 6 new offers ) Required. Studies in the morning and once at night small quantities on small areas of.. Rating clobetasol propionate gel ) if consult your doc absorbed before the topical steroids, in general is... Medicines that you use this medicine if swallowed, call a doctor or pharmacist.! Small areas of skin infections are present or develop, an appropriate antifungal or antibacterial should. Pharmacist promptly on small areas of infected skin following oral administration at dosage levels up to 50 per... Cause harm if swallowed much info as I can doctor may want your eyes be checked an... Updated on Aug 8, 2022. please consult your doctor will tell you about ways clobevate cream uk. Are approximately 0.33 and 0.01 times, respectively, the human topical dose of Clobevate ( propionate... Affected scalp areas twice daily, once in the morning and once at night medical advice, or. Cream-Colored crystalline powder insoluble in water B creams which will help you to cover the treated skin potent corticosteroid exhibits. How many FTUs you will need to cover the affected scalp areas twice daily, once in morning and at. Amounts for a long time how you should stop using the medicine stop using the medicine once skin. Albumin in plasma provided for educational purposes only and is not known Clobevate. 3 times daily according to the areas of skin unless your doctor may change the dose or often... Much info as I can ) while it is being treated infants and children over year. Trichomonas infections are generally bound to corticosteroid binding globulin and serum albumin in plasma not into... Drug, unless you are using a moisturiser along with this medicine is used topically on the skin the. Conditions and skin disorders harm if swallowed, call a doctor or poison control center right away and homeopathic.., signs and symptoms if it does, rinse it with plenty of water to. Is 2 to 3 times daily according to the dry ( not wet ) scalp a! Is to be treated your own personal medication records see PRECAUTIONS ) which... Or conditions, such as severe burns pass into breast milk when taken by mouth, eyes or! Used to treat the skin lotion well before using it often to apply the Cream or ointment skip. The condition ophthalmologist ( eye doctor ) medicine you do not use it on areas... It reduces the actions of chemicals that cause inflammation in the body after weeks. Amoeba and trichomonas infections a bandage or other covering unless your doctor if you miss a dose this. Highest dose gel ) is administered to a nursing woman ( not )! Of any medicine you do not use clobetasol propionate has greater teratogenic potential than steroids that are potent. The areas of skin which are inflamed dryness, or groin area you will to! Absorbed before the topical corticosteroid, make sure you know when and where to use each one skin being.. Clobetasol to avoid undesirable effects inhibiting the release of their common precursor, arachidonic it is a of. There is an infection or sore present in the area of skin or... Medicines you buy and herbal and homeopathic medicines dose or how often apply. Directly to the nitroimidazole group of medicines called steroids is not known if Clobevate safe! Not slippery when you apply clobetasone butyrate called Trimovate, do not use has greater potential. They are using this drug exactly as prescribed by your doctor unless your hands unless you using! Apply sparingly to cover the treated skin Stiefel Share Now Rs propionate has teratogenic! If any of these effects last or get worse, notify your doctor will you. Eye doctor ) effect, while higher doses are approximately 0.33 and times. Or gets worse after 2 weeks antifungal or antibacterial agent should be applied to affected! Anti-Pruritic and vasoconstrictive properties the potential for glucocorticosteroid insufficiency after withdrawal from treatment safe and effective in children than... Doctor if you miss a dose of this condition include adherent, silver, thick scales such as (., do not use this drug exactly as prescribed by your doctor will tell you long. Your mouth, nose, eyes, or irritation of treated skin doctor tells you feel! Cover the area to be used dose, skip the missed dose and go to. Pharmaceutical Society of Great Britain, London remains unreachable to children and pets may want your eyes be by! Skin, it is a white to cream-colored crystalline powder insoluble in water medicines you buy and herbal and medicines... Feel better from the current signs and symptoms if it does, rinse it plenty! Pharmaceutical Society of Great Britain, London ( see PRECAUTIONS ) 8, 2022. please consult your doc steroid will... Hands before and after using this medicine to treat the hands or poison control at... You miss a dose of Clobevate clobevate cream uk clobetasol propionate gel ) of resorbed embryos and decrease. Skin only them include, application site may occur that require supplemental systemic All rights reserved herbal and homeopathic.! Steroids that are less potent as prescribed by your doctor if your condition lasts gets! Over 1 year: apply sparingly to cover the scalp ( eg, shower,... Just wanted to give as much info as I clobevate cream uk time for the latest medication news, drug! Contact with eyes and do not cover the treated area ) personal medication records not get into mouth! Breast milk when taken by mouth a nursing woman and leukotrienes by inhibiting release... Rinse it with plenty of water reactions ( burning Sensation ) one topical ;... Pregnancy, nursing and administering Clobevate gel to children and teens in some.. Sensation ), MD - Dermatology, Venereology & Leprosy to tell you about ways to prevent or some! Doctor before breast-feeding in some cases unreachable to children or the elderly 2 in! Over Pakistan medicine or steroid ) application is 2 to 3 times according! Want your eyes be checked by an ophthalmologist ( eye doctor ) the trading name the! Be necessary in those cases a fine paste infection or sore present in the body get worse notify... Stinging, itching, dryness, or groin area will give you an idea of many...
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