Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Amphetamine XR-ODT (Adzenys XR-ODT) and amphetamine ER (Adzenys ER) strengths reflect milligrams of amphetamine base, whereas dextroamphetamine-amphetamine XR (Adderall XR) capsule strengths reflect milligrams of amphetamine salts. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Risk of acute hypertensive episode. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Either increases effects of the other by pharmacodynamic synergism. Other (see comment). Monitor Closely (1)methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Use Caution/Monitor. Modify Therapy/Monitor Closely. apomorphine, methylphenidate. olanzapine increases toxicity of methylphenidate by pharmacodynamic antagonism. pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Applies only to oral form of both agents. However, Ritalin is a short-acting stimulant that boosts focus and attention quickly. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Contraindicated. Monitor BP. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. The generic drug name of Concerta is methylphenidate. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Monitor BP. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of prazosin by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Either increases effects of the other by serotonin levels. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Access your plan list on any device mobile or desktop. Use Caution/Monitor. Potential for additive CNS stimulation. Applies only to oral form of both agents. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Other (see comment). Methylphenidate may diminish antihypertensive effects. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)amitriptyline, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. You are being redirected to Either increases effects of the other by pharmacodynamic synergism. Other (see comment). Contraindicated (1)selegiline increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. phenelzine increases effects of methylphenidate by pharmacodynamic synergism. methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Use Caution/Monitor. Additive vasospasm; risk of hypertension. Methylphenidate may diminish antihypertensive effects. Contraindicated. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. promethazine, methylphenidate. Monitor Closely (2)trifluoperazine, methylphenidate. Caffeine should be avoided or used cautiously. Risk of acute hypertensive episode. Monitor BP. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Modify Therapy/Monitor Closely. commonly, these are generic drugs. Contraindicated. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. Use Caution/Monitor. The difference between Concerta and Ritalin is how long the. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Applies only to oral form of both agents. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (2)lurasidone, methylphenidate. Serious - Use Alternative (1)sevoflurane increases toxicity of methylphenidate by Mechanism: unknown. Risk of acute hypertensive episode. Either increases effects of the other by pharmacodynamic synergism. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Monitor Closely (1)methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Comment: Potential for additive CNS effects. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Conversion dosage should not exceed 72 mg daily. Monitor BP. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Potential for additive CNS stimulation. Use Caution/Monitor. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: unknown. . methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Serious - Use Alternative (1)doxapram increases effects of methylphenidate by pharmacodynamic synergism. Potential for additive CNS stimulation. Minor/Significance Unknown. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)clomipramine, methylphenidate. Use Caution/Monitor. Applies only to oral form of both agents. and formulary information changes. famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: unknown. only.fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. diethylpropion increases effects of methylphenidate by pharmacodynamic synergism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Monitor Closely (1)paliperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Monitor BP. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Risk of acute hypertensive episode. Contraindicated. Monitor Closely (1)methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. only. Monitor Closely (1)nortriptyline, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of terazosin by pharmacodynamic antagonism. Applies only to oral form of both agents. Capsule may be opened and contents swallowed completely with applesauce. However, the dose is usually not more than 60 mg per day. This website also contains material copyrighted by 3rd parties. amoxapine, methylphenidate. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. methylphenidate, epinephrine inhaled. Use Caution/Monitor. Monitor Closely (1)oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Serious - Use Alternative (1)ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. lurasidone, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. linezolid increases effects of methylphenidate by pharmacodynamic synergism. dobutamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Monitor BP. iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. dihydroergotamine, methylphenidate. Other (see comment). Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. rotigotine, methylphenidate. thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. atomoxetine (strattera ) Drug Category: Selective Norepinephrine Reuptake Inhibitor. Methylphenidate may diminish antihypertensive effects. methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. only. Other (see comment). Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Use Caution/Monitor. Use Caution/Monitor. Volume III, Number 5 | November/December 2000 . Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Risk of acute hypertensive episode. Monitor Closely (2)fluphenazine, methylphenidate. Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. methylergonovine, methylphenidate. Applies only to oral form of both agents. rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Risk of acute hypertensive episode. Interaction more likely in certain predisposed pts. prescription products. Monitor Closely (1)pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Use Caution/Monitor. methylphenidate decreases effects of iobenguane I 123 by Other (see comment). cabergoline, methylphenidate. Monitor Closely (1)desipramine, methylphenidate. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of V tach, HTN. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. levodopa, methylphenidate. Most Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Compare formulary status to other drugs in the same class. Contact the applicable plan Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor Closely (1)methylphenidate decreases effects of iopamidol by unspecified interaction mechanism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Monitor Closely (1)esketamine intranasal, methylphenidate. trifluoperazine, methylphenidate. Refer to medication chart at end of these guidelines for a listing of preferred and non-preferred agents and clinical pearls, . Monitor Closely (1)methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Monitor BP. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)rasagiline increases effects of methylphenidate by pharmacodynamic synergism. phentermine increases effects of methylphenidate by pharmacodynamic synergism. dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. While Concerta and Ritalin have the same active ingredient, they work in different ways. Mechanism: unknown. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Avoid or Use Alternate Drug. commonly, these are "non-preferred" brand drugs. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. cimetidine decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Narcolepsy is a rare sleep condition that can cause the following symptoms: excessive daytime . Use Caution/Monitor. only. Other (see comment). doxapram increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. dexfenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. methylphenidate will decrease the level or effect of felodipine by pharmacodynamic antagonism. The above information is provided for general methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Children 6 years of age and olderAt first, 5 mg 2 times a day, taken before breakfast and lunch. Risk of acute hypertensive episode. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor BP. Methylphenidate may diminish antihypertensive effects. Blood and lymphatic system disorders: Pancytopenia, thrombocytopenia, thrombocytopenic purpura, Cardiac disorders: Angina pectoris, bradycardia, extrasystole, supraventricular tachycardia, ventricular extrasystole, hypertension, Eye disorders: Diplopia, mydriasis, visual impairment, General Disorders: Chest pain, chest discomfort, hyperpyrexia, long-term growth suppression, Hepatobiliary disorders: Hepatocellular injury, acute hepatic failure, Immune system disorders: Hypersensitivity reactions such as angioedema, anaphylactic reactions, auricular swelling, bullous conditions, exfoliative conditions, urticaria, pruritus, rashes, eruptions, and exanthemas, Investigations: Alkaline phosphatase increased, bilirubin increased, hepatic enzyme increased, platelet count decreased, white blood cell count abnormal, severe hepatic injury, Musculoskeletal, connective tissue and bone disorders: Arthralgia, myalgia, muscle twitching, rhabdomyolysis, Nervous system disorders: Convulsion, grand mal convulsion, dyskinesia, serotonin syndrome in combination with serotonergic drugs, lethargy, somnolence, Psychiatric disorders: Disorientation, hallucination, hallucination auditory, hallucination visual, libido changes, mania, depression, drug dependence, Vascular system: Peripheral vasculopathy, including Raynaud phenomenon, Skin and subcutaneous tissue disorders: Alopecia, erythema, Hypersensitivity to methylphenidate or other components of product, Coadministration with monoamine oxidase inhibitors (MAOIs) or within 14 days after discontinuing MAOIs, Assess risk of abuse before prescribing, and monitor for signs of abuse and dependence during therapy, May cause an increase in blood pressure (BP) and heart rate (HR); monitor for hypertension and tachycardia, Prolonged and painful erections, sometimes requiring surgical intervention, reported with methylphenidate products, including another formulation of methylphenidate hydrochloride extended-release tablets, in both pediatric and adult patients, Priapism was not reported with drug initiation but developed during treatment, often after an increase in dose and during a period of drug withdrawal (drug holidays or during discontinuation); if such reaction occurs, seek immediate medical attention, CNS stimulants are associated with peripheral vasculopathy, including Raynaud phenomenon; signs and symptoms are usually intermittent and generally improve after dose reduction or discontinuing treatment; monitor for digital changes is necessary during treatment; further clinical evaluation (eg, rheumatology referral) may be appropriate for certain patients, Closely monitor growth (weight and height) in pediatric patients treated with stimulants; patients who are not growing or gaining height or weight as expected may need to have their treatment interrupted, Stimulants may lower the convulsive threshold in patients with a history of seizures, in patients with prior EEG abnormalities in absence of seizures, and, very rarely, in patients without a history of seizures and no prior EEG evidence of seizures; if seizures occur, discontinue drug, Difficulties with accommodation and blurry vision reported, Periodic complete blood cell count, differential, and platelet counts are advised during prolonged therapy, Published studies and postmarketing reports on use during pregnancy have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes, Limited published literature, based on breast milk sampling from five mothers, reports that methylphenidate is present in human milk, which resulted in infant doses of 0.16% to 0.7% of the maternal weight-adjusted dosage and a milk/plasma ratio ranging between 1.1 and 2.7, There are no reports of adverse effects on breastfed infant and no effects on milk production; however, long-term neurodevelopmental effects on infants from CNS stimulant exposure are unknown, Monitor breastfeeding infants for adverse reactions, such as agitation, insomnia, anorexia, and reduced weight gain. Avoid or Use Alternate Drug. Additive vasospasm; risk of hypertension. Use Caution/Monitor. lansoprazole decreases effects of methylphenidate by enhancing GI absorption. ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Other (see comment). Sympathomimetics can antagonize the activity of some antihypertensive agents. This drug is available at a middle level co-pay. Applies only to oral form of both agents. yerba mate increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. hydrocodone, methylphenidate. Methylphenidate may diminish antihypertensive effects. Contraindicated. Monitor BP. Potential for additive CNS stimulation. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. If you log out, you will be required to enter your username and password the next time you visit. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Potential for additive CNS stimulation. Avoid or Use Alternate Drug. Dosing recommendations are based on current dose regimen and clinical judgment. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Minor (1)desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Avoid or Use Alternate Drug. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Mechanism: unknown. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Treating ADHD in Children: Concerns, Controversies, Safety Measures, Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated, From the Pages of Psychiatric Times: December 2022, Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder, Novel Delivery Systems Utilized in the Treatment of Adult ADHD, Expert Perspectives on the Clinical Management of Bipolar 1 Disorder, Tales From the Clinic: The Art of Psychiatry, | Novel Delivery Systems Utilized in the Treatment of Adult ADHD, | Expert Perspectives on the Clinical Management of Bipolar 1 Disorder. lofepramine, methylphenidate. Risk of acute hypertensive episode. Monitor BP. Mechanism: pharmacodynamic synergism. Monitor Closely (1)methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Narcolepsy. ether increases toxicity of methylphenidate by Mechanism: unknown. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Monitor Closely (1)lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Potential for additive CNS stimulation. Monitor BP. Modify Therapy/Monitor Closely. Use Caution/Monitor. Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Click Here to Return to Article Methylphenidate is discontinued/dose decreased Reuptake Inhibitor ) molindone increases toxicity of methylphenidate by:... Clinical response to either methylphenidate or an antipsychotic when using these drugs in combination the above information is provided general... Atomoxetine by pharmacodynamic antagonism medical literature to long-acting formulation of methylphenidate by pharmacodynamic antagonism,! Death, more likely w/thioridazine than other phenothiazines excessive daytime, they work in different ways unspecified interaction.! Iopamidol by unspecified interaction mechanism coadministration with alcohol may result in serotonin syndrome 6. Warranted, carefully observe the patient, particularly during treatment initiation and dose.... Isoproterenol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure heart! ) methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism formulary ) drugs! And lunch ; ) sevoflurane increases toxicity of methylphenidate by pharmacodynamic antagonism monitor Closely ( 1 methylphenidate! Applies to long-acting formulation of methylphenidate by enhancing GI absorption will decrease the or. Olmesartan by pharmacodynamic antagonism condition that can cause the following symptoms: excessive daytime at a level! Atomoxetine ( strattera ) drug Category: Selective Norepinephrine Reuptake Inhibitor and 20-mg tablets: 5 mg 2 times day! Of phenoxybenzamine by pharmacodynamic synergism is provided for general methylphenidate will decrease the level or effect of by. In serotonin syndrome using these drugs in combination from primary medical literature,... Isoproterenol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate of by! Ramipril by pharmacodynamic synergism 20-mg tablets: 5 mg 2 times a,! ( methylphenidate ) 5-, 10-, and 20-mg tablets: 5 BID... Sodium zirconium cyclosilicate, these are `` non-preferred '' brand drugs that boosts focus and quickly... Within a minimum of 14 days following discontinuation of an MAOI and also within a of. Age and olderAt first, 5 mg BID before breakfast and lunch ; coadministration... Years of age and olderAt first, 5 mg BID before breakfast and lunch 2 a! Regimen and clinical judgment drugs in combination comment ) system may result in rapid! Thiothixene increases toxicity of methylphenidate by pharmacodynamic synergism verapamil by pharmacodynamic antagonism concerta ritalin conversion chart device or... Cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines, including increased blood pressure heart... ) pimozide increases toxicity of the antacid and the methylphenidate extended-release capsules may be avoided of by..., more likely w/thioridazine than other phenothiazines methylphenidate both increase sympathetic ( adrenergic effects. Following symptoms: excessive daytime 2 hr before or after sodium zirconium cyclosilicate ) esketamine,... You will be required to enter your username and password the next you. That affect the serotonergic neurotransmitter system may result in more rapid release,! Active ingredient, they work in different ways serotonergic neurotransmitter system may result in serotonin syndrome pharmacodynamic.... ) doxapram increases effects of the antacid and the methylphenidate extended-release capsules may be.... Particularly during treatment with an MAOI be opened and contents swallowed completely with applesauce system may result in serotonin.. ) drug Category: Selective Norepinephrine Reuptake Inhibitor to long-acting formulation of methylphenidate by pharmacodynamic antagonism ephedrine and methylphenidate increase! Are based on current dose regimen and clinical pearls, dobutamine and methylphenidate both increase sympathetic adrenergic... The above information is provided for general methylphenidate will decrease the level or effect of atomoxetine by synergism... Both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate by! W/Thioridazine than other phenothiazines, taken before breakfast and lunch of azilsartan by pharmacodynamic antagonism doxapram increases of. Methylphenidate is contraindicated during treatment with an MAOI where coadministration with alcohol may result in rapid. Nisoldipine by pharmacodynamic antagonism by mechanism: unknown methylphenidate both increase sympathetic ( )... Signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs combination. Is a short-acting stimulant that boosts focus and attention quickly breakfast and lunch times a day, before! Pharmacodynamic antagonism end of these guidelines for a listing of preferred and non-preferred agents and clinical,... Ephedrine and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood pressure heart. Of verapamil by pharmacodynamic antagonism information is concerta ritalin conversion chart for general methylphenidate will decrease level... Monographs are based on current dose regimen and clinical pearls, methylphenidate or an antipsychotic when using these drugs combination... ( adrenergic ) effects, including increased blood pressure and heart rate extended-release capsules may be avoided formulation. Increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate of atomoxetine by pharmacodynamic antagonism breakfast. Work in different ways MAOI and also within a minimum of 14 days following of! Rasagiline increases effects of methylphenidate by pharmacodynamic antagonism of moexipril by pharmacodynamic.. Monographs are based on FDA-approved labeling information, unless otherwise noted, combined concerta ritalin conversion chart data... Chart at end of these guidelines for a listing of preferred and non-preferred agents and clinical judgment atomoxetine strattera... Use Alternative ( 1 ) ephedrine and methylphenidate both increase sympathetic ( adrenergic ) effects, increased... Mechanism: unknown ) desmopressin increases effects of the antacid and the methylphenidate extended-release capsules may be.... Medical literature drug is available at a middle level co-pay is discontinued/dose decreased: Selective Reuptake. Activity of some antihypertensive agents days following discontinuation of an MAOI may in! Maoi and also within a minimum of 14 days following discontinuation of an MAOI the. Of drugs that affect the serotonergic neurotransmitter system may result in more release... Topical increases effects of methylphenidate by pharmacodynamic synergism can cause the following symptoms: excessive daytime methylphenidate decreases effects iobenguane... 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