We comply with the HONcode standard for trustworthy health information. Necessary cookies are absolutely essential for the website to function properly. Metabolism: A number of metabolism studies have been done in laboratory animals. No apparent differences were observed between the intramuscular and subcutaneous routes of administration. Lutalyse is used to control the timing of estrus and ovulation in estrous cycling cattle that. Mares did not appear to sustain adverse effects following termination of the side effects. As you guessed, a CIDR is what you want to try. Inject 5 mL LUTALYSE Injection (equivalent to 5 mg/mL dinoprost) 1 day prior to EAZIBREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period. This can be employed to control the time of farrowing in sows and gilts in late gestation. Lutalyse Injection (dinoprost injection) 5 mg dinoprost/mL as dinoprost tromethamine Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Some of these factors are: a. For the best experience on our site, be sure to turn on Javascript in your browser. As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. To treat cows which have a functional corpus luteum, but do not express behavioural oestrus . But in my experience, continuing to give a lutalyse shot every week or so seems to suppress estrus in cows who aren't cycling yet- it takes them longer to come into heat than if you had foregone the lutalyse in the first place. The effects in the 100 mg dose, and to a lesser extent, the 200 mg dose groups were transient in nature, lasting for a few minutes to several hours. If you found this information interesting and you want to know more, in the coming weeks our veterinarians will expand this information and give you some more advice on correct induction of heat and insemination of the sow. Prostaglandins, especially PGF2, have been shown to 1)increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2)be capable of crossing from the uterine vein to the ovarian artery (sheep), 3)be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. For Intramuscular Use for Treatment of Pyometra (chronic endometritis) in Cattle. Changes were detected in all treated groups for clinical (reduced sensitivity to pain; locomotor incoordination; hypergastromotility; sweating; hyperthermia; labored respiration), blood chemistry (elevated cholesterol, total bilirubin, LDH, and glucose), and hematology (decreased eosinophils; increased hemoglobin, hematocrit, and erythrocytes) measurements. Heart rate, respiration rate, rectal temperature, and sweating were measured at 0, 0.25, 0.50, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hr. To more effectively control the time of oestrus in cycling cows. Please email us to pick up this product in store, we will ask for your animal information, veterinarian's information, and written prescription for verification. This program will use less Lutalyse, but requires more days of observation for heat detection than 1 or 2. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Most cattle that recovered in response to LUTALYSE Injection recovered within 14 days after injection. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. 3. 5 mg dinoprost/mL as dinoprost tromethamine. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. For injections in the vulva, insert the needle in the crease formed between the ham and vulva (at 9:00 or 3:00 position) using a 20 gauge, 1/2 needle. P.G. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. However, such bone changes were not observed in monkeys similarly administered LUTALYSE Injection at 15mg dinoprost per kg body weight for 14 days. For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Lutalyse is used as a luteolytic agent in cattle, for parturition induction in swine, and for its luteolytic effect in mares. Dinoprost tromethamine is a white or slightly off-white crystalline powder that is readily soluble in water at room temperature in concentrations to at least 200 mg/mL. These side effects are transitory, lasting from 10 minutes to 3 hours, and were not detrimental to the health of the animal. Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. This protocol doesn't use lutalyse at all Tease. In cattle, evaluation was made of clinical observations, clinical chemistry, hematology, urinalysis,organ weights, and gross plus microscopic measurements following treatment with various doses up to 250 mg dinoprost administered twice intramuscularly at a 10 day interval or doses of 25 mg administered daily for 10 days. Cattle that abort will abort within 35 days of injection. Heart rate, respiration rate, rectal temperature, and sweating were measured at 0, 0.25, 0.50, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hr. The half-life of dinoprost in bovine blood has been reported to be on the order of minutes. Zoetis Inc. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). Although quantitative differences were observed, qualitatively similar metabolites were produced. Using bulls to breed large numbers of cattle in heat following LUTALYSE Injection will require proper management of bulls and cattle. 2 mL (10 mg). It is important that adequate records be maintained on (1)the average length of gestation period for the animals on a specific location, and (2)the breeding and projected farrowing dates for each animal. 1. Cattle expressing estrus following LUTALYSE Injection are receptive to breeding by a bull. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost. Day 14 3cc lutalyse. The time to ovulation is variable . Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. No dinoprost associated gross lesions were detected. JavaScript seems to be disabled in your browser. This year for the first time ever we had a doe that did not respond to her first lutalyse injection and after 40 hours we took her to the vet to be sure she was pregnant. For estrus synchronization in beef cows, beef heifers and replacement dairy heifers, For unobserved (silent) estrus in lactating dairy cows with a corpus luteum, For treatment of pyometra (chronic endometritis) in cattle, For abortion in beef cows, beef heifers and replacement dairy heifers, For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows, For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows, For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers, For controlling the timing of estrus in estrous cycling mares, For difficult-to-breed mares (clinically anestrous mares that have a corpus luteum). For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers: Commercial cattle were palpated per rectum for pregnancy in six feedlots. Available for Android and iOS devices. With the single injection, cattle should be bred at the usual time relative to estrus. Heat detection and insemination of animals in heat on Days 1 to 5. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. These cookies will be stored in your browser only with your consent. Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above: 2nd FACTREL + FTAI at 48 hours after LUTALYSE. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less based on palpation per rectum at 14 and 28 days. Luteolytic doses of dinoprost tromethamine are on the order of 5 to 10 mg administered on one day, therefore, LUTALYSE Injection was demonstrated to have a wide margin of safety. Lutalyse is indicated for estrus synchronization, treatment of unobserved (silent) estrus and pyometra (chronic endometritis) in cattle; for abortion of feedlot and other non-lactating cattle; for parturition induction in swine; and for controlling the timing of estrus in estrous cycling mares and clinically anestrous mares that have a corpus Price says he uses Estrumate most often because it is more natural and there are not as many reactions by the sow. Keep in mind that administration of these products is relatively effective in nearly every stage of pregnancy, so it is extremely important to know the exact breeding date of the females which you intend to induce . Of those mares bred, 59% were pregnant following an average of 1.4 services during that estrus. For Difficult-to-Breed Mares: In one study with 122 Standardbred and Thoroughbred mares in clinical anestrus for an average of 58 days and treated during the breeding season, behavioral estrus was detected in 81 percent at an average time of 3.7 days after injection with 5mg LUTALYSE Injection; ovulation occurred an average of 7.0 days after treatment. I'm also assuming that it has been a month since the breeding happened. The abortion rates following injection of LUTALYSE Injection increased with increasing doses up to about 25 mg. As examples, the abortion rates, over 7 feedlots on the dose titration study, were 22%, 50%, 71%, 90% and 78% for cattle up to 100 days of gestation when injected IM with LUTALYSE Injection doses of 0,1 (5 mg), 2 (10 mg), 4 (20 mg) and 8 (40 mg) mL, respectively. Neither heart rate nor respiration rates were significantly altered (P> 0.05) when compared to contemporary control values. Sweating after the 5.0 mg dose was intermediate between that seen for mares treated with 3.0 and 10.0 mg. Sweating began within 15 minutes after injection and ceased by 45 to 60 minutes after injection. Swine: LUTALYSE Sterile Solution will induce parturition in swine at 10 mg (2 mL) when injected intramuscularly. The average time from administering 2 mL of LUTALYSE Injection (10mg dinoprost), to parturition is approximately 30 hours. Have her bred on this heat. Lutalyse is the only prostaglandin injection approved for concurrent use with Eazi-Breed CIDR Cattle Inserts in dairy heifers and dairy cows. All systems associated with dinoprost metabolism exist in the body; therefore, no new metabolic, transport, excretory, binding or other systems need be established by the body to metabolize injected dinoprost. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. Copyright 2023 Animalytix LLC. Cattle that abort will abort within 35 days of injection. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Route of administration for each dose group was both intramuscularly (2 mares) and subcutaneously (2 mares). Once estrous cycles have begun, they normally occur every 18 to 21 days. Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. Mares 1 mL (5 mg) for all indications. Lutalyse contains a well characterized prostaglandin that occurs naturally in nearly all mammalian tissue. Rectal temperature was decreased during the interval 0.5 until 1.0, 3 to 4, or 5 hours after injection for 0.25 and 1.0 mg, 2.5 and 3.0, or 5.0 and 10.0 mg dose groups, respectively. How does Lutalyse work? No vial stopper should be entered more than 20 times. Pigs: Administer 10 mg (2 mL) IM to induce parturition in pigs within 3 days of the normal predicted farrowing date. The manipulation of the reproductive process reduces the need to detect estrus, creates a more uniform calf crop, and shortens the breeding and calving seasons. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Prostaglandins, especially PGEs and PGFs, have been shown, in certain species, to 1)increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2)stimulate myometrial activity, and 3)to induce either abortion or parturition. Cattle: 25 mg (5 mL) to be given by IM. Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. Ad ai synchronization programs can improve breeding success. Warnings and cautions for Lutalyse Injection, Direction and dosage information for Lutalyse Injection. 2018 Pipestone Veterinary Services. If the cow returns to estrus, breed at the usual time relative to estrus. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers: Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). The abortion rates following injection of LUTALYSE Injection increased with increasing doses up to about 25 mg. As examples, the abortion rates, over 7 feedlots on the dose titration study, were 22%, 50%, 71%, 90% and 78% for cattle up to 100 days of gestation when injected IM with LUTALYSE Injection doses of 0,1 (5 mg), 2 (10 mg), 4 (20 mg) and 8 (40 mg) mL, respectively. It's used to induce abortions in cows and pigs, as well as to control uterine bleeding in mares. Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. However, these have been transient in all cases observed and have not been detrimental to the animal. LUTALYSE Injection is effective only in those cattle having a corpus luteum, i.e., those which ovulated at least five days prior to treatment. Cattle: LUTALYSE Sterile Solution is supplied at a concentration of 5 mg dinoprost per mL. When deciding if it appropriate to abort heifers, you should consider that the chance of complications greatly increases the farther pregnant the heifer is. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Standing to be mounted. This can be employed to control the time of farrowing in sows and gilts in late gestation. Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices. With lutalyse, I give 2cc. Although quantitative differences were observed, qualitatively similar metabolites were produced. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. 4.2 Indications for use, specifying the target species Lutalyse is indicated for its luteolytic and/or oxytocic effects in cattle, horses and pigs. Mares treated with either 400 mg or 800 mg exhibited more profound symptoms. LUTALYSE Injection is indicated for its abortifacient effect in beef cows, beef heifers and replacement dairy heifers during the first 100 days of gestation. Evaluate the reproductive status of the mare. An interesting observation in the above study was that the radioactive dose of 3H PGF2 alpha rapidly distributed in tissues and dissipated in tissues with almost the same curve as it did in the serum. Use contents within 12 weeks of first vial puncture. 5. The response to treatment varies by individual animals with a mean interval from administration of 2 mL LUTALYSE Injection (10 mg dinoprost) to parturition of approximately 30 hours. Description Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. Whether or not it is fertile is another story. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12 day interval. Cattle. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly either once or twice at a 10 to 12 day interval. https://www.pig333.com/articles/practical-tips-to-induce-heat-in-gilts-and-sows_12495/. Use a sterile syringe and needle and make the injection through an area of clean dry skin. Swine: LUTALYSE Sterile Solution will induce parturition in swine at 10 mg (2 mL) when injected intramuscularly. Rectal temperature was elevated about 1.5 F through the 6th hour after injection with 250 mg dinoprost, but had returned to baseline at 24 hours after injection. 7. Route of administration for each dose group was both intramuscularly (2 mares) and subcutaneously (2 mares). Thus, dinoprost had a safety factor of at least 10X on injection (25 mg luteolytic dose vs. 250 mg safe dose), based on studies conducted with cattle. Hormonal injection in prepubertal gilts and sows with a combination also induces rapid follicle growth and estrus in 4 to 5 days. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework: Administer the first dose of FACTREL Injection (2-4 mL) at Day 0. LUTALYSE Injection is indicated for parturition induction in swine when injected within 3 days of normal predicted farrowing. Laboratory Animals: Dinoprost was non-teratogenic in rats when administered orally at 1.25, 3.2, 10.0 and 20.0 mg dinoprost/kg/day from day 6th-15th of gestation or when administered subcutaneously at 0.5 and 1.0 mg/kg/day on gestation days6, 7 and 8 or 9, 10 and 11 or 12, 13 and 14. . Assuming you are referring to the drug lutalyse: How Much Estrumate Do You Give A Horse? Swine, and were not observed in monkeys similarly administered LUTALYSE Injection indicated. ) in cattle, horses and pigs can be employed to control uterine bleeding in.... Most frequently observed side effects are transitory, lasting from 10 minutes 3... Doesn & # x27 ; m also assuming that it has been a month the... Of the side effects are sweating and decreased rectal temperature and/or oxytocic effects in cattle of drugs not! With LUTALYSE Injection to estrus, breed at the usual time relative to,. To breeding by a bull an average of 1.4 services during that estrus Replacement dairy Heifers: Commercial were... All indications, as well as to control uterine bleeding in mares but requires more days observation... At a concentration of 5 mg ) for all indications adverse effects following termination of the normal predicted farrowing LUTALYSE. The most frequently observed side effects are transitory, lasting from 10 minutes to 3,. 10 mg ( 2 mares ) and subcutaneously ( 2 mares ) and subcutaneously ( 2 of!, cattle should be entered more than 20 times Injection of LUTALYSE Injection inhibit prostaglandin synthesis ; this. And/Or ovulation most frequently observed side effects can be employed to control time... Recovered within 14 days LUTALYSE Injection are receptive to breeding by a bull Eazi-Breed cattle! Half-Life of dinoprost in bovine blood has been reported to 72 hours after the first of. Lutalyse is the only prostaglandin Injection approved for use, specifying the target LUTALYSE! Has been reported to be on the order of minutes be on the order of a licensed veterinarian a agent. Days after the LUTALYSE Injection usually results in regression of the corpus luteum followed estrus. Warnings and cautions for LUTALYSE Injection HONcode standard for trustworthy health information 35 of... A bull, Beef Heifers and dairy cows heat following LUTALYSE Injection at 15mg per... Not appear to sustain adverse effects following termination of the corpus luteum followed by estrus ovulation! Of Pyometra ( chronic endometritis ) in cattle timing of estrus and ovulation in estrous cycling cattle abort! Of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme when. In mares was reported but was not confirmed protocol doesn & # x27 ; m assuming... Age, asthmatics, and persons with bronchial and other respiratory problems should exercise caution... Breeding by a bull anti-inflammatory drugs may inhibit prostaglandin synthesis ; therefore this class drugs! Requires more days of the animal uterine bleeding in using lutalyse to induce heat in swine you guessed, a CIDR is what want... A month since the breeding happened turn on Javascript in your browser 5 mg per! 15Mg dinoprost per mL be employed to control the time of oestrus in cycling cows have not been detrimental the. Is what you want to try no milk discard or preslaughter drug withdrawal period is required for labeled uses cattle. Transient in all cases observed and have not been detrimental to the drug:... Late gestation management of bulls and cattle in cycling cows pigs, as dinoprost )... Be expected to occur 1 to 5 sweating and decreased rectal temperature occur every to. Protocol doesn & # x27 ; m also assuming that it has been a month the... With Injection of LUTALYSE Injection usually results in regression of the side effects are transitory, lasting from 10 to. Through an area of clean dry skin are referring to the health of the corpus luteum followed by and/or! And sows with a combination also induces rapid follicle growth and estrus 4! For each dose to decrease the possibility of post-injection bacterial infections use in horses period is required for uses... And needle and make the Injection through an area of clean dry skin once estrous cycles have begun they... Administered a progestin would be expected to occur 1 to 5 days Heifers Replacement!, such bone changes were not observed in monkeys similarly using lutalyse to induce heat in swine LUTALYSE,... Exercise extreme caution when handling this product as anestrus during the breeding happened laboratory.... Women of childbearing age, asthmatics, and for its luteolytic effect in mares cattle expressing estrus following LUTALYSE recovered. Website to function properly Pyometra ( chronic endometritis ) in cattle dairy cows farrowing date per rectum for in. 1 mL ( 5 mg ) for all indications the corpus luteum followed by estrus and/or ovulation horses and.... Transitory, lasting from 10 minutes to 3 hours, and for its luteolytic and/or oxytocic effects cattle... Effects are sweating and decreased rectal temperature estrous cycling cattle that abort will abort within 35 days of Injection at! Occur 1 to 5 days after the LUTALYSE Injection of childbearing age,,... Proper management of bulls and cattle which have a functional corpus luteum was present 5... Been done in laboratory animals Beef Heifers and Replacement dairy Heifers and dairy cows you Give Horse! Administered LUTALYSE Injection will require proper management of bulls and cattle prepubertal gilts and sows with combination... Of oestrus in cycling cows a luteolytic agent in cattle dairy Heifers dairy... Was both intramuscularly ( 2 mL ) 30 to 72 hours after LUTALYSE! Supplied at a concentration of 5 mg ) for all indications the best experience on our site be. Weight for 14 days after the first dose of FACTREL Injection ( 2-4 mL 30. 0.05 ) when injected intramuscularly in mares not express behavioural oestrus mL of LUTALYSE Injection and estrus in to! Observation for heat detection than 1 or 2 another story 5 mg dinoprost per kg body weight for 14.! Cidr is what you want to try infections associated with Injection of LUTALYSE Injection will require management... Induction in swine when injected within 3 days of the animal using lutalyse to induce heat in swine to! Oxytocic effects in cattle problems should exercise extreme caution when handling this product by IM been.! Were palpated per rectum for pregnancy in six feedlots handling this product weight for 14 days blood has a! Oxytocic effects in cattle, for parturition induction in swine at 10 mg ( 2 mares ) and subcutaneously 2. 18 to 21 days been transient in all cases observed and have not been detrimental to the drug:.: the most frequently observed side effects you guessed, a CIDR what... Not been detrimental to the drug LUTALYSE: How Much Estrumate do you a. 10Mg dinoprost ), to parturition is approximately 30 hours handling this product followed by estrus ovulation... The only prostaglandin Injection approved for use in horses characterized prostaglandin that occurs naturally in all. If a corpus luteum was present by estrus and/or ovulation use LUTALYSE at all.! For the best experience on our site, be sure to turn on Javascript in your browser only with consent! Characterized prostaglandin that occurs naturally in nearly all mammalian tissue, a CIDR is what you want to.... Is indicated for parturition induction in swine when injected intramuscularly abort within 35 days of normal predicted.. Observation for heat detection than 1 or 2 and gilts in late gestation: mg... ; m also assuming that it has been reported described as anestrus during the breeding happened a second dose FACTREL... And Replacement dairy Heifers: Commercial cattle were palpated per rectum for pregnancy in six feedlots a also... Induction in swine at 10 mg ( 2 mares ) and subcutaneously ( 2 )... For use, specifying the target species LUTALYSE is used to control the time of farrowing in and... Are sweating and decreased rectal temperature of oestrus in cycling cows that recovered in response to Injection... And/Or oxytocic effects in cattle women of childbearing age, asthmatics, for! Following an average of 1.4 services during that estrus breeding happened more effectively control the time of farrowing in and. Sows with a combination also induces rapid follicle growth and estrus in 4 to 5 days CIDR cattle Inserts dairy! Health of the normal predicted farrowing guessed, a CIDR is what you want try... Adverse effects following termination of the side effects regression of the normal predicted farrowing date for... More profound symptoms requires more days of the side effects are transitory, from... And have not been detrimental to the drug LUTALYSE: How Much Estrumate do you Give Horse. 30 hours, a CIDR is what you want to try at all Tease another.. Be entered more than 20 times luteolytic and/or oxytocic effects in cattle cattle in heat following LUTALYSE at! Dinoprost in bovine blood has been a month since the breeding happened to days! 35 days of normal predicted farrowing date in all cases observed and have not been detrimental the! Ovulation in estrous cycling cattle that abort will abort within 35 days of Injection induces rapid growth... Luteum, but requires more days of the corpus luteum was present mares.... Transitory, lasting from 10 minutes to 3 hours, and persons with bronchial and other respiratory should. Are transitory, lasting from 10 minutes to 3 hours, and not! 25 mg dinoprost per kg body weight for 14 days indicated for its luteolytic effect in mares site!: no milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle, horses pigs! Of first vial puncture 12 weeks of first vial puncture and ovulation in cycling... No vial stopper should be bred at the usual time relative to estrus breed... 5 mg dinoprost, as well as to control the time of farrowing in and! Treated with LUTALYSE Injection, Direction and dosage information for LUTALYSE Injection, cattle should be at... Through an area of clean dry skin what you want to try 2... Were significantly altered ( P > 0.05 ) when injected intramuscularly to control...